Ann McDermott’s research group studies the structure, flexibility, and function of proteins using magnetic resonance methods. For example, we study the structure and function of potassium ion channels, which play crucial roles in diverse contexts, from bacteria to the human nervous system. Our work illuminated the role of an ion-depleted state and provided evidence for strong allosteric coupling in channel regulation, using the prototypical prokaryotic ion channel KcsA. As for many enzymes and drug targets, ligand binding is associated with internal motions. The characteristic timescales of active-site flexible loop motions in other proteins have been studied in the past by the McDermott group, and ongoing studies of the channel position us to carry out detailed dynamics of the channel.